Velonia Research Group

List of Publications

40. Theodorou, A., Raptis V., Baltzaki, C. I. M., Manios, T., Harmandaris, V., Velonia K. Synthesis and Modeling of Poly(L-lactic acid) via Polycondensation of L-Lactic Acid Polymers 2023, 15, 4569.
https://doi.org/10.3390/polym15234569
39. Maragkaki, A., Tsompanidism C., Velonia, K., Manios, T. Pilot-Scale Anaerobic Co-Digestion of Food Waste and Polylactic Acid Sustainability 2023, 15 10944.
https://www.mdpi.com/2071-1050/15/14/10944
38. Voutyritsa, E., Gryparis, C., Theodorou, A., Velonia, K. Synthesis of Multifunctional Protein-Polymer Conjugates via Oxygen-tolerant, Aqueous Copper-Mediated Polymerization and Bioorthogonal Click Chemistry Macromol. Rapid Commun. 2023, 2200976.
https://doi.org/10.1002/marc.202200976
37. Theodorou, A., Gounaris, D., Voutyritsa, E., Andrikopoulos, N., Baltzaki, C. I. M., Anastasaki, A., Velonia, K. Rapid Oxygen-Tolerant Synthesis of Protein-Polymer Bioconjugates via Aqueous Copper-Mediated Polymerization Biomacromolecules 2022, 23, 4241–4253.
https://doi.org/10.1021/acs.biomac.2c00726
36. Papadimitriou, L., Theodorou, A., Papageorgiou, M., Voutyritsa, E., Papagiannaki, A., Velonia, K., Ranella, A. pH responsive biohybrid BSA-poly(DPA) nanoparticles for interlysosomal drug delivery J. Drug. Deliv. Sci. Technol. 2022 75, 103591.
doi.org/10.1016/j.jddst.2022.103591
35. Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., Chen, C. Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine J. Am. Chem. Soc. 2022 144, 9184–9205.
doi.org/10.1021/jacs.2c02277
34. Hudita, A., Radu, I. C., Galateanu, B., Ginghina, O., Herman, H., Balta, C., Rosu, M., Zaharia, C., Costache, M., Tanasa, E., Velonia, K., Tsatsakis A., Hermenean, A. Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro Nanotoxicology 2021 15:7, 973-994.
doi.org/10.1080/17435390.2021.1943032
33. Theodorou, A., Mandriotis, P., Anastasaki, A. Velonia, K. Oxygen tolerant, photoinduced controlled radical polymerization approach for the synthesis of giant amphiphiles Polym. Chem. 2021, 12, 2228-2235.
DOI: 10.1039/D0PY01608J
32. Andrikopoulos, N., Li, Y., Cecchetto, L., Nandakumar, A., Da Ros, T., Davis, T. P., Velonia K., Ke, P. -C. Nanomaterials synthesis, an enabler of amyloidosis inhibition against human diseases Nanoscale 2020, 12 14422.
DOI: 10.1039/D0NR04273K
31. Theodorou, A., Liarou, E., Haddleton, D.M., Stavrakaki, I. G., Skordalidis, P., Whitfield, R., Anastasaki, A., Velonia, K. Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach Nat. Commun. 2020, 11, 1486.
DOI: 10.1038/s41467-020-15259-z
30. Sedyakina, N., Kuskov, A., Velonia, K., Feldman, N., Lutsenko, S., Avramenko G. Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein-Drug Delivery System Materials 2020, 13, 1989.
DOI: 10.3390/ma13081989
29. Basyrev, L. Y. Voinov, E. V., Gusev, A. A., Mikhalchik, E.V., N. Kuskov, A. N., Goryachay, A. V., Gusev, S. A., Shtilman M. I., Velonia, K., Tsatsakis, A. M. Fluorouracil neutrophil extracellular traps formation inhibited by polymer nanoparticle shielding Mater. Sci. Eng. C 2020, 108, 110382.
DOI: 10.1016/j.msec.2019.110382
28. Tsatsakis, A. M., Stratidakis, A. K., Goryachaya, A. V., Tzatzarakis, M. N., Stivaktakis, P. D., Docea, A. O., Berdiaki, A., Nikitovic, D., Velonia, K., Shtilman, M. I., Rizos, A. K., Kuskov, A. N. In vitro blood compatibility and in vitro cytotoxicity of amphiphilic poly-N-vinylpyrrolidone nanoparticles Food Chem. Toxicol. 2019, 127, 42-52.
DOI: 10.1016/j.fct.2019.02.041
27. Radu, I. C., Hudita, A., Zaharia, C., Galateanu, B., Iovu, H., Tanasa, E. (V)., Nitu, S. G., Ginghina, O., Negrei, C., Tsatsakis, A., Velonia, K., Costache, M. Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer Drug Deliv. 2019, 26, 318-327.
DOI: 10.1080/10717544.2019.1582729
26. Liarou, E., Whitfield, R., Anastasaki, A., Engelis, N. G., Jones, G. R., Velonia, K., Haddleton, D. M. Copper-Mediated Polymerization without External Deoxygenation or Oxygen Scavengers Angew. Chem. Int. Ed. 2018, 57, 8998-9002.
DOI: 10.1002/anie.201804205
25. Golichenari, B., Velonia, K., Nosrati, R., Nezami, A., Farokhi-Fard, A., Abnous, K., Behravan, J., Tsatsakis, A. M. Label-free nano-biosensing on the road to tuberculosis detection Biosens. Bioelectron. 2018, 113, 124-135.
DOI: 10.1016/j.bios.2018.04.059
24. Luss, A. L., Kulikov, P. P., Romme, S. B., Andersen, C. L., Pennisi, C. P., Docea, A. O., Kuskov, A. N., Velonia, K., Mezhuev, Y. O., Shtilman, M.I., Tsatsakis, A. M., Gurevich, L. Nanosized carriers based on amphiphilic poly-N-vinyl-2-pyrrolidone for intranuclear drug delivery Nanomedicine 2018, 13, 703-715.
DOI: 10.2217/nnm-2017-0311
23. Kuskov, A. N., Kulikov, P. P., Goryachaya, A. V., Tzatzarakis, M. N., Tsatsakis, A. M., Velonia, K., Shtilman, M. I. Self-assembled amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for hydrophobic drugs: Stability aspects J. Appl. Polym. Sci. 2018, 135, 45637.
DOI: 10.1002/app.45637
22. Radu, I. -C., Hudita, A., Zaharia, C., Stanescu, P. O., Vasile, E., Iovu, H., Stan, M., Ginghina, O., Galateanu, B., Costache, M., Langguth, P., Tsatsakis, A., Velonia, K., Negrei, C. Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer Front. Pharmacol. 2017, 8, 508.
DOI: 10.3389/fphar.2017.00508
21. Kuskov, A. N., Kulikov, P. P., Goryachaya, A. V., Tzatzarakis, M. N., Docea, A. O., Velonia, K., Shtilman, M. I., Tsatsakis, A. M. Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13, 1021-1030.
DOI: 10.1016/j.nano.2016.11.006
20. Ioannou, C. P., Ioannou, G. I., Moushi, E. E., Velonia, K., Chronakis, N. Self-Assembled Giant Vesicles Formed by Type I [3:3]-Hexakis Adducts of C₆₀ Equipped with Enantiomerically Pure cyclo-Monomalonate Addends Eur. J. Org. Chem. 2015, 4598-4602.
DOI: 10.1002/ejoc.201500504
19. Daskalaki, Ε., Le Droumaguet, Β., Gérard, D., Velonia, K. Multifunctional Giant Amphiphiles via simultaneous copper(I)-catalyzed azide-alkyne cycloaddition and living radical polymerization Chem. Commun. 2012, 48, 1586-1588.
DOI: 10.1039/c1cc15075h
18. Velonia, K. Protein-polymer amphiphilic chimeras: recent advances and future challenges Polym. Chem. 2010, 1, 944-952.
DOI: 10.1039/b9py00362b
17. Le Droumaguet, B., Velonia, K. In situ ATRP-Mediated hierarchical formation of giant amphiphile bionanoreactors Angew. Chem. Int. Ed. 2008, 47, 6263-6266.
DOI: 10.1002/anie.200801007
16. Le Droumaguet, Velonia, K. Click chemistry: A powerful tool to create polymer-based macromolecular chimeras Macromol. Rapid Commun. 2008, 29, 1073-1089.
DOI: 10.1002/marc.200800155
15. Le Droumaguet, B., Mantovani, G., Haddleton, D. M., Velonia, K. Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates J. Mater. Chem. 2007, 17, 1916-1922.
DOI: 10.1039/b618079e
14. Flomenbom, O., Hofkens, J., Velonia, K., de Schryver, F. C., Rowan, A. E., Nolte, R. J. M., Klafter, J., Silbey, R. J. Correctly validating results from single molecule data: The case of stretched exponential decay in the catalytic activity of single lipase B molecules Chem. Phys. Lett. 2006, 432, 371-374.
DOI: 10.1016/j.cplett.2006.10.060
13. Thordarson, P. Le Droumaguet, B. Velonia, K. Well-defined protein-polymer conjugates-synthesis and potential applications Appl. Microbiol. Biotechnol. 2006, 73, 243-254.
DOI: 10.1007/s00253-006-0574-4
12. Hatzakis, N. S., Engelkamp, H., Velonia, K., Hofkens, J., Christianen, P. C. M., Svendsen, A., Patkar, S. A., Vind, J., Maan, J. C., Rowan, A. E., Nolte, R. J. M. Synthesis and single enzyme activity of a clicked lipase-BSA hetero-dimer Chem. Commun. 2006, 19, 2012-2014.
DOI: 10.1039/b516551b
11. Hoogboom J., Velonia, K., Rasing, T., Rowan, A. E., Nolte R. J. M. LCD-based detection of enzymatic action Chem. Commun. 2006, 4, 434-435.
DOI: 10.1039/b514048j
10. Lindström M., Bouilly S., Velonia K., Smonou I., Hedenström E. Synthesis of diastereo- and enantiomerically pure anti-3-methyl-1,4-pentanediol via lipase catalysed acylation Tetrahedron Asymmetry 2005, 1355-1360.
DOI: 10.1016/j.tetasy.2005.01.043
9. Mantovani, G., Lecolley, F., Tao, L. Haddleton, D. M., Clerx, J., Cornelissen, J. J. L. M., Velonia, K. Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: A suitable alternative to PEGylation chemistry J. Am. Chem. Soc., 2005, 127, 2966-2973.
DOI: 10.1021/ja0430999
8. Flomenbom, O., Velonia, K., Loos, D., Masuo, S., Cotlet, M. Engelborghs, Y., Hofkens, J., Rowan, A. E., Nolte, R. J. M., van der Auweraer, M., de Schryver, F. C., Klafter, J. Stretched exponential decay and correlations in the catalytic activity of fluctuating single lipase molecules Proc. Natl. Acad. Sci. USA, 2005, 102, 2368-2372.
DOI: 10.1073/pnas.0409039102
7. Velonia, K., Flomenbom, O., Loos, D., Masuo, S., Cotlet, M., Engelborghs, Y., Hofkens, J., Rowan, A. E., Klafter, J., Nolte, R. J. M., de Schryver, F. C. Single-enzyme kinetics of CALB-catalyzed hydrolysis Angew. Chem. Int. Ed. 2005, 44, 560-564.
DOI: 10.1002/anie.200460625
6. Vriezema D. M., Hoogboom J., Velonia K., Takazawa K., Christianen P. C. M., Maan J. C., Rowan A. E., Nolte R. J. M. Vesicles and polymerized vesicles from thiophene-containing rod-coil block copolymers Angew. Chem. Int. Ed. 2003, 42, 772-776.
DOI: 10.1002/anie.200390204
5. Velonia K., Rowan A. E., Nolte R. J. M. Lipase polystyrene giant amphiphiles J. Am. Chem. Soc. 2002, 124, 4224-4225.
DOI: 10.1021/ja017809b
4. Velonia K., Smonou I. Stereospecificity of hydride transfer during the dismutation of aldehydes catalyzed by alcohol dehydrogenases Tetrahedron Asymmetr. 2001, 12, 3119-3123.
DOI: 10.1016/S0957-4166(01)00551-1
3. Velonia K., Smonou I. Dismutation of aldehydes catalyzed by alcohol dehydrogenases J. Chem. Soc. Perkin Trans. 1 2000, 14, 2283-2287.
DOI: 10.1039/b001039l
2. Velonia K., Tsigos I., Bouriotis V., Smonou Ι. Stereospecificity of hydrogen transfer by the NAD⁺-linked alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123 Bioorg. Med. Chem. Lett. 1999, 9, 65-68.
DOI: 10.1016/S0960-894X(98)00678-7
1. Tsigos I., Velonia K., Smonou I., Bouriotis V. Purification and characterization of an alcohol dehydrogenase from the Antarctic psychrophile Moraxella sp. TAE123 Eur. J. Biochem. 1998, 254, 356-362.
DOI: 10.1046/j.1432-1327.1998.2540356.x