Title: Innovative technologies for implantable orthopaedic devices

Abstract

The Istituto Ortopedico Rizzoli has played a pioneering role in the development of orthopaedic implants, from the early contributions of Codivilla to the advances under Pizzoferrato in biomaterials research and biocompatibility testing. Building on this historical trajectory, the Institute has explored a wide range of implant designs, supported by histological examinations that clarified mechanisms of pro-osteointegration. Particular emphasis has been placed on prosthesis surface bioengineering, with innovative coating strategies and deposition techniques such as ionized jet deposition (IJD), aimed at enhancing implant fixation and biological affinity. Despite these advances, aseptic loosening and peri-implant infections remain major clinical challenges. Prevention strategies combine material surface modifications with microbiological insights to reduce bacterial colonization and improve host response. By integrating progress in material science, cell biology, and microbiology, Rizzoli’s research exemplifies how multidisciplinary approaches can drive the next generation of implantable medical devices toward improved safety, functionality, and patient outcomes.